Enabling Environments for Non-communicable Disease Risk Reduction in Ethiopia

Recruiting now · Not applicable

Conditions studied: Non-communicable Diseases (NCD)

In brief

The ENABLE study focuses on pregnant women attending routine antenatal care (ANC) in urban primary health care facilities in four Ethiopian cities. Many women in this setting face increased health risks due to unhealthy diets, low physical activity, and exposure to air pollution which can affect both maternal and newborn health and increase the risk of non-communicable diseases (NCDs) later in life. In this study, pregnant women in intervention health centers receive structured, tailored counseling as part of their regular ANC visits. This counseling supports healthier eating, physical activity and reduced exposure to air pollution. Health care providers, including health workers in health centers and Urban Health Extension Professionals (UHEPs), are trained to deliver this counseling supported by a digital ANC eRegistry for clinical decision-making, which enhances adherence to national guidelines, and strengthens the quality of care. Facilitators further strengthen the intervention's implementation by ensuring fidelity to counseling protocols and by adapting content to the Ethiopian urban health system context. The study hypothesis is that integrating lifestyle counseling into routine ANC will improve maternal health behaviors and pregnancy outcomes, and reduce NCD risk among pregnant women, compared with standard routine ANC alone. By embedding NCD prevention within routine maternal health services, the ENABLE study aims to strengthen the role of ANC as a platform for early prevention and long-term health benefits for women and their children.

Key facts

Study ID

NCT07442318

Run by

Norwegian Institute of Public Health

People needed

1268

Starts

2026-05-11

Expected to finish

2027-05-01

Last updated by the study team

2026-05-28

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Pregnant women aged 18 years or older
• Gestational age ≤20 weeks at the time of enrollment
• Residing in one of the four study cities (Addis Ababa, Adama, Harar, or Jimma)
• Attending their first antenatal care visit at one of the participating public health facilities
• Willing and able to provide informed consent

You may not qualify if…

• Pregnant women identified as high risk at enrollment, including those with pre-existing medical conditions, or other conditions requiring specialized care and who cannot continue receiving standard routine ANC.

Where it is running

• Addis Ababa — Addis Ababa, Addis Ababa, Ethiopia (enrolling)
• Harar — Harar, Harare, Ethiopia (enrolling)
• Adama — Ādama, Oromiya, Ethiopia (enrolling)
• Jimma — Jimma, Oromiya, Ethiopia (enrolling)

Full record on ClinicalTrials.gov

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