Evaluation of Muscle Strength and Muscle Mass in Patients With Inflammatory Bowel Disease

Recruiting now

Conditions studied: Crohn Disease (CD)

In brief

This prospective observational study aims to evaluate the validity of ultrasonographic muscle measurements in patients with inflammatory bowel disease (IBD). Sarcopenia is commonly assessed using computed tomography (CT)-based skeletal muscle area measurements at the L3 vertebral level, which are considered a gold standard method. However, CT is not always feasible due to radiation exposure and accessibility limitations. In this study, muscle strength will be assessed using handgrip dynamometry, and muscle mass will be evaluated using ultrasonography of selected skeletal muscles. In patients with available recent abdominal CT imaging, L3 skeletal muscle area will be recorded. The primary objective is to compare ultrasonographic muscle measurements with CT-based assessments and to evaluate the agreement between these methods. This study aims to determine whether ultrasonography can serve as a practical and reliable alternative tool for muscle mass evaluation in patients with IBD.

Key facts

Study ID

NCT07441447

Run by

Sakarya University

People needed

100

Starts

2025-11-10

Expected to finish

2026-12-01

Last updated by the study team

2026-03-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Established diagnosis of inflammatory bowel disease (ICD-10: K50.* Crohn's disease, K51.* ulcerative colitis)
• Ability to provide written informed consent
• Ability to undergo ultrasonographic muscle assessment and handgrip strength testing
• Availability of an abdominal computed tomography (CT) scan performed within the previous 6 months

You may not qualify if…

• Known neuromuscular disorders or primary muscle diseases
• Major orthopedic conditions affecting muscle strength assessment
• Pregnancy
• Abdominal wall defects or conditions interfering with ultrasound assessment
• Incomplete clinical or imaging data
• Any condition preventing reliable ultrasound or handgrip measurement

Where it is running

• Sakarya University Faculty of Medicine, Training and Research Hospital — Sakarya, Adapazarı, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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