Does Circadian Misalignment Have Sex-Specific Effects on Metabolism?

Starting soon · Not applicable

Conditions studied: Circadian Misalignment, Sex Differences

In brief

This study will test whether biological sex influences how the body responds to circadian misalignment-a mismatch between the internal body clock and the timing of sleep and eating (as can occur with shift work or jet lag). Researchers will examine how circadian misalignment affects appetite regulation (hunger/fullness) and glucose metabolism (blood sugar control), and whether these effects differ between females and males. Findings may help inform more personalized shift work schedules and targeted strategies to reduce metabolic health risks and sex-related differences in clinical care.

Key facts

Study ID

NCT07441265

Run by

Brigham and Women's Hospital

People needed

36

Starts

2026-10-01

Expected to finish

2030-09-30

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 18-40 years of age
• Body Mass Index 18.5-24.9 kg/m2
• Non-smokers, no current tobacco or e-cigarette use
• Healthy with no acute or chronic medical and psychiatric disorders
• Sex assigned at birth consistent with reproductive anatomy at enrollment (per protocol definition)

You may not qualify if…

• History of drug or alcohol dependency
• History of psychiatric illness or disorder
• Pregnant
• No prior gender-affirming hormone therapy and no gonadectomy

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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