Timing of Subcostal TAPB Combined With Rectus Sheath Block for Postoperative Pain After Laparoscopic Cholecystectomy

Recruiting now · Not applicable

Conditions studied: Postoperative Pain, Laparoscopic Cholecystectomy

In brief

This prospective randomized controlled trial aims to evaluate whether the timing of ultrasound-guided subcostal transversus abdominis plane (TAP) block combined with rectus sheath block (RSB) affects postoperative pain in patients undergoing laparoscopic cholecystectomy. Participants will be randomly assigned to receive the combined regional blocks either before surgical incision or after completion of surgery. The primary outcome is postoperative pain intensity measured using a numerical rating scale. Secondary outcomes include opioid consumption, incidence of postoperative nausea and vomiting, and other recovery parameters. The results of this study may help optimize the timing of abdominal wall blocks to improve postoperative analgesia and recovery following laparoscopic cholecystectomy.

Key facts

Study ID

NCT07440940

Run by

Eulji University Hospital

People needed

96

Starts

2026-02-23

Expected to finish

2027-01-15

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Elective laparoscopic cholecystectomy
• Adults aged 18 to 80 years
• Ability to understand the study procedures and provide informed consent
• American Society of Anesthesiologists (ASA) physical status I-III

You may not qualify if…

• Presence of significant pain unrelated to the target disease that may interfere with pain assessment
• Known allergy or contraindication to study medications (ropivacaine, acetaminophen, nefopam, or pethidine)
• Planned single-port laparoscopic cholecystectomy
• American Society of Anesthesiologists (ASA) physical status IV or higher
• Infection of the abdominal wall or skin at the injection site, or anatomical abnormalities of the abdominal wall
• Major neurological, psychiatric, or systemic diseases that may affect pain perception, treatment response, or study evaluation
• Requirement for postoperative mechanical ventilation
• Pregnancy or breastfeeding
• Considered unsuitable for the study by the investigator
• Refusal to participate or inability to provide informed consent

Where it is running

• Nowon Eulji University Hospital — Seoul, South Korea (enrolling)

Full record on ClinicalTrials.gov

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