Restrictive vs Liberal Intraoperative Fluid Strategy and Postoperative Outcomes After Elective Cesarean Section
Recruiting now · Not applicable
Conditions studied: Cesarean Section, Postoperative Nausea and Vomiting (PONV), Postdural Puncture Headache (PDPH), Postoperative Ileus, Gastrointestinal Recovery
In brief
Spinal anesthesia for elective cesarean section is frequently associated with hemodynamic instability and postoperative complications such as postoperative nausea and vomiting (PONV) and delayed gastrointestinal recovery. Although intraoperative fluid administration is routinely used to prevent spinal-induced hypotension, the optimal fluid strategy remains unclear. Both restrictive and liberal fluid approaches may influence maternal hemodynamics and postoperative outcomes through different physiological mechanisms. This prospective, single-center, randomized controlled trial aims to compare restrictive (≤3 mL/kg/h) and liberal (\>3 mL/kg/h) intraoperative crystalloid fluid strategies in patients undergoing elective cesarean section under spinal anesthesia. The primary outcome is the incidence of PONV within the first 24 hours postoperatively. Secondary outcomes include postdural puncture headache (PDPH), time to first flatus, hypotension frequency, and vasopressor requirements.
Key facts
- Study ID
- NCT07440667
- Run by
- Nigde Omer Halisdemir University
- People needed
- 160
- Starts
- 2026-03-04
- Expected to finish
- 2027-01-30
- Last updated by the study team
- 2026-03-10
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Female patients aged 18-45 years
- ASA physical status II
- Scheduled for elective cesarean section under spinal anesthesia
- Provision of written informed consent
You may not qualify if…
- Emergency cesarean section
- Preeclampsia or eclampsia
- Known cardiac failure
- Known renal failure
- Known hepatic failure
- Coagulopathy
- Contraindication to spinal anesthesia
- Conversion to general anesthesia
- Major technical complications during spinal anesthesia
- Refusal to participate
Where it is running
- Niğde Ömer Halisdemir University Hospital — Niğde, Merkez, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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