Evaluation of the Efficacy of Corticosteroids in Septic Arthritis in Adults
Starting soon · Phase 2 · Has a placebo group
Conditions studied: Septic Arthritis
In brief
Septic arthritis is a severe infection associated with significant morbidity and mortality. Despite eradication of the microorganisms, persistent inflammation may lead to substantial long-term functional joint sequelae. The use of corticosteroids could reduce this inflammation, thereby improving functional joint outcomes and facilitating first-line medical treatment. The hypothesis of this study is that corticosteroid administration, in addition to antibiotic therapy, reduces persistent inflammation and improves functional joint prognosis in adult patients with acute septic arthritis.
Key facts
- Study ID
- NCT07440238
- Run by
- Assistance Publique - Hôpitaux de Paris
- People needed
- 200
- Starts
- 2026-03-30
- Expected to finish
- 2026-09-01
- Last updated by the study team
- 2026-02-27
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Documented septic arthritis (microorganism identified intra-articularly by culture or PCR, or by turbid synovial fluid with positive Gram stain, or positive blood cultures)
- Effective antibiotic therapy initiated within ≤ 3 days
- Effective contraception for women of childbearing age during treatment period
- Signed informed consent
- Affiliation to the French national health insurance system
- Ability to read, write, and understand French
You may not qualify if…
- Polyarticular septic arthritis (≥ 2 joints)
- Septic arthritis of small joints (e.g., fingers: proximal interphalangeal joint (PIP), distal interphalangeal joints (DIP), MetaCarpoPhalangeal (MCP); toes: MTP)
- Systemic sclerosis
- Pyomyositis
- Diabetic foot infection
- Current corticosteroid therapy for another indication
- Inability to take oral medication
- Contraindication to corticosteroids
- Associated endocarditis
- Presence of prosthetic joint or osteosynthesis material in the affected joint
- Septic shock
- Severe soft tissue wound overlying the joint
- Aplastic chemotherapy
- Neutropenia (defined as neutrophils < 500/mm³)
- Mycobacterial infection
- Fungal infection
- Sickle cell disease
- Current pregnancy
- Breastfeeding women
- Patients under legal protection (e.g., guardianship)
- Participation in another interventional clinical trial
- Uncontrolled diabetes
- Unstable psychiatric disorders
- Adults unable to provide informed consent
- Contraindication to corticosteroid therapy
Where it is running
- Hopital Robert Ballanger — Aulnay-sous-Bois, France
Full record on ClinicalTrials.gov
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