Definitive Hypofractionated Intensity-modulated Radiation Theraphy With Concurrent Chemotherapy in Cervical Cancer
Recruiting now · Phase 2
Conditions studied: Cervical Cancer
In brief
This study aims to evaluate the efficacy and safety of hypofractionated intensity-modulated radiation therapy (IMRT) combined with concurrent chemotherapy in patients with cervical cancer. Conventional treatment usually requires 7-8 weeks, which increases the risk of toxicities and treatment delays. This trial seeks to shorten the overall treatment time while maintaining non-inferior tumor response and survival outcomes compared to standard therapy. The primary endpoint is tumor volume reduction rate (TVRR) assessed by pelvic MRI at 1 month after treatment. Secondary endpoints include 3-year local recurrence rate, progression-free survival, and incidence of acute and late grade ≥3 toxicities. The results of this study are expected to contribute to establishing an optimal treatment strategy for cervical cancer.
Key facts
- Study ID
- NCT07439497
- Run by
- Samsung Medical Center
- People needed
- 34
- Starts
- 2025-12-09
- Expected to finish
- 2028-05-30
- Last updated by the study team
- 2026-02-27
Who can join
Age: 20 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed cervical cancer (squamous cell carcinoma, adenocarcinoma, or adenosquamous carcinoma)
- FIGO stage IIB-IVA (2018)
- Measurable primary tumor on pelvic MRI within 30 days prior to treatment initiation
- Age ≥ 20 years
- ECOG performance status 0-1
- Adequate bone marrow function: WBC ≥ 3,000/µL, ANC ≥ 1,000/µL, platelets ≥ 100,000/µL, hemoglobin ≥ 9 g/dL
- Adequate renal function: Creatinine < 2.0 mg/dL
- Ability to provide written informed consent
You may not qualify if…
- Patients with distant metastasis
- Patients who have previously received pelvic radiotherapy
- Patients who have previously received definitive chemotherapy or chemoradiotherapy for diagnosed cervical cancer
- Patients who have undergone surgery for the current cervical cancer lesion
- Patients who underwent local excisional procedures of the cervix such as conization or Loop Electrosurgical Excision Procedure (LEEP) prior to radiotherapy
- Patients who are unable to undergo concurrent chemoradiotherapy due to poor general condition
- Patients with other active malignancies (except carcinoma in situ of the cervix, basal cell carcinoma of the skin, or superficial bladder cancer) within 3 years prior to enrollment or who experienced recurrence within 3 years after treatment
Where it is running
- Samsung Medical Center — Seoul, Gangnam-gu, South Korea (enrolling)
Full record on ClinicalTrials.gov
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