AGE and CALLY Index in Familial Mediterranean Fever

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Conditions studied: Familial Mediterranean Fever

In brief

Familial Mediterranean Fever (FMF) is an autoinflammatory disease characterized by recurrent inflammatory attacks and persistent low-grade inflammation. Even during attack-free periods, subclinical inflammation may continue and contribute to long-term complications. Advanced glycation end products (AGEs) are molecules that accumulate under chronic inflammatory and oxidative stress conditions. AGEs can be measured non-invasively using skin autofluorescence (SAF). The C-reactive protein-albumin-lymphocyte (CALLY) index is a composite marker derived from routine laboratory parameters and reflects systemic inflammation and nutritional status. This observational cross-sectional study aims to evaluate the association between skin autofluorescence-measured AGE levels and the CALLY index in patients with FMF. The study will also compare AGE levels between FMF patients and age- and sex-matched healthy controls. The study does not involve any intervention, treatment assignment, or randomization. All laboratory parameters will be obtained from routine clinical evaluations, and AGE measurement will be performed using a non-invasive device.

Key facts

Study ID

NCT07439341

Run by

Bursa City Hospital

People needed

150

Starts

2026-02-01

Expected to finish

2026-11-01

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• For FMF Patients:
• Age between 18 and 65 years
• Diagnosis of Familial Mediterranean Fever according to Tel-Hashomer criteria
• At least 6 months of clinical follow-up
• Available routine laboratory data (CRP, albumin, lymphocyte count)
• Not in an acute FMF attack at the time of assessment
• Ability to provide written informed consent
• For Healthy Controls:
• Age between 18 and 65 years
• No history of chronic inflammatory, autoimmune, metabolic, or renal disease
• Ability to provide written informed consent

You may not qualify if…

• Diagnosis of diabetes mellitus
• Chronic kidney disease stage 3 or higher
• Active infection
• Malignancy within the past 5 years
• Dermatologic condition affecting the forearm measurement site
• Use of high-dose antioxidant or vitamin supplementation within the past 3 months
• Any condition that, in the opinion of the investigators, may interfere with study participation

Full record on ClinicalTrials.gov

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