Post-Amputation Stump Infection as a Predictor of Persistent Residual Limb Pain: A Prospective Cohort Study

Starting soon

Conditions studied: Residual Limb Pain, Stump Pain, Post-Amputation Pain, Surgical Site Infection, Phantom Limb Pain (PLP)

In brief

Persistent residual limb pain is common after traumatic amputation and significantly impairs rehabilitation and prosthetic use. Postoperative stump infection may contribute to peripheral nerve sensitization, scar fibrosis, and long-term pain persistence. This prospective cohort study aims to determine whether early post-amputation stump infection independently predicts persistent clinically significant residual limb pain at 3 and 6 months after surgery.

Key facts

Study ID

NCT07438795

Run by

Ukrainian Society of Regional Anesthesia and Pain Therapy

People needed

150

Starts

2026-06-23

Expected to finish

2026-12-23

Last updated by the study team

2026-06-03

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Traumatic upper or lower limb amputation
• Enrollment within 4 weeks after surgery
• Ability to provide informed consent

You may not qualify if…

• Pre-existing chronic pain in the affected limb
• Severe cognitive impairment
• Terminal illness limiting follow-up
• Refusal or inability to complete follow-up assessments

Full record on ClinicalTrials.gov

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