Ultrasound Predictors of Persistent Burn Scar Pain After Blast and Drone-Related Injuries: A Prospective Cohort Study
Starting soon
Conditions studied: Burn Scar Pain, Neuropathic Pain, Combat-Related Burn Injury, Scar-Related Pain
In brief
Persistent burn scar pain is common after blast and drone-related injuries and may be driven by scar fibrosis, vascular activity, and peripheral nerve involvement within scar tissue. This prospective cohort study aims to determine whether early ultrasound features of scars and nerves predict persistent clinically significant scar pain at 3 and 6 months. Ultrasound measures include scar thickness, echogenicity, Power Doppler vascularity, dynamic adhesion (gliding) assessment, and ultrasound signs of nerve involvement ("US-nerve positive"). Clinical outcomes include pain intensity (NRS), neuropathic pain screening (DN4), and functional interference.
Key facts
- Study ID
- NCT07438769
- Run by
- Ukrainian Society of Regional Anesthesia and Pain Therapy
- People needed
- 150
- Starts
- 2026-03-24
- Expected to finish
- 2026-05-23
- Last updated by the study team
- 2026-02-27
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Burn injury with clinically formed scar
- Enrollment 2-12 weeks after injury
- Scar located on extremities, chest wall, or neck
- Ability to provide written informed consent
You may not qualify if…
- Severe cognitive impairment preventing valid questionnaires
- Hemodynamic instability or inability to complete baseline evaluation
- Active systemic infection (enrollment deferred until stable)
- Pre-existing chronic pain condition unrelated to burn scar that would confound outcomes (investigator judgment)
Where it is running
- Vinnitsya Regional Clinical Hospital n.a Pirogov — Vinnitsya, Select, Ukraine
Full record on ClinicalTrials.gov
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