Effect of Mediterranean vs Paleolithic Diet on RA Activity, Sarcopenia and QOL: 12-Week RCT

Recruiting now · Not applicable

Conditions studied: Rheumatoid Arthritis (RA)

In brief

This study aims to evaluate the effects of Mediterranean and Paleolithic dietary interventions on nutritional status, disease activity, fatigue, sleep, and quality of life in adults with rheumatoid arthritis (RA). Participants aged 40-60 years will be randomly assigned to follow either a Mediterranean diet, a Paleolithic diet, or continue their usual diet for 12 weeks. The study will assess anthropometric measurements, disease activity score (DAS28), laboratory biomarkers (CBC, CRP, ESR, lipid profile, fasting glucose, HbA1c), and patient-reported outcomes. The trial will determine whether these diets improve RA management and overall well-being.

Key facts

Study ID

NCT07438652

Run by

Kasr El Aini Hospital

People needed

75

Starts

2026-01-17

Expected to finish

2026-07-15

Last updated by the study team

2026-02-27

Who can join

Age: 40 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients classified as having rheumatoid arthritis according to the 2010 rheumatoid arthritis ACR/ EULAR classification criteria with a selected age group of 40 to 60 years old.

You may not qualify if…

• Patients with comorbidities (e.g., diabetes mellitus, hypertension, gout, thyroid dysfunction).

Where it is running

• Kasr Al Ainy Hospital, Faculty of Medicine, Cairo University — Cairo, Al-Manial, Egypt (enrolling)

Full record on ClinicalTrials.gov

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