Adding Magnesium Sulphate to Combined Pectointercostal Plane and Erector Spinae Plane Blocks for Acute and Chronic Post-Mastectomy Pain

Starting soon · Not applicable

Conditions studied: Post-mastectomy Pain Syndrome

In brief

Given the burden of chronic postmastectomy pain and the need for effective, opioid-sparing analgesia, the propose of the randomized controlled trial is to evaluate the safety and efficacy of adding magnesium sulphate to the combination of PIP block and ESPB in patients undergoing modified radical mastectomy for reducing acute and chronic post mastectomy pain

Key facts

Study ID

NCT07438366

Run by

South Egypt Cancer Institute

People needed

60

Starts

2026-02-15

Expected to finish

2027-02-15

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients aged ≥18 years.
• American Society of Anesthesiologists (ASA) class I-III.
• Scheduled for unilateral modified radical mastectomy.

You may not qualify if…

• Known allergy to local anesthetics or magnesium.
• Coagulopathy or anticoagulant therapy.
• Local infection at injection site.
• Body mass index (BMI) ≥ 40 kg/m2.
• Chronic opioid use or chronic pain disorders.
• Neurological or psychiatric disorders affect pain perception.
• Severe hepatic or renal impairment.
• Pregnancy.
• Lactation.

Full record on ClinicalTrials.gov

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