VEXUS-REA : Evaluation of Ultrasound Parameters of Venous Congestion in Patients in a Medical Intensive Care Unit

Starting soon · Not applicable

Conditions studied: Venous Congestion

In brief

Shock is a common and serious cause of admission to intensive care. Vascular filling is one of the cornerstones of shock treatment, aimed at increasing cardiac output and restoring adequate organ perfusion through rapid intravenous administration of a solution. However, this vascular filling can be accompanied by venous congestion, which can be harmful. Fluid administration must therefore be sparing and carefully considered. However, it is difficult to assess the correct amount of intravenous fluid to inject. Multi-site venous ultrasound (inferior vena cava, suprahepatic vein, portal vein, renal vein), recently published under a score called VExUS, could be a useful bedside tool for documenting venous congestion and avoiding excessive vascular filling. Nevertheless, this tool has been little evaluated in the general intensive care population, particularly in patients with acute respiratory distress syndrome (ARDS). Its link with other venous sites (femoral, popliteal) has also been little studied to date. The main objective of our study is to describe the distribution of the VEXUS score among patients in a general intensive care unit. The secondary objectives are: * To study the feasibility of measuring the VEXUS score in patients with ARDS, including during prone positioning, a recommended and frequently used treatment for this condition, which could make it difficult to acquire venous ultrasound data. * In this case, other more accessible venous flows could be analysed, namely the femoral venous flow and the popliteal venous flow. We will therefore also study their feasibility during prone positioning sessions. * Subsequently, we will study the correspondence between the VEXUS score and these other types of venous flow (femoral, popliteal). * Finally, we will evaluate the association between the VEXUS score in our general intensive care population and the long-term prognosis of patients, in this case death on day 28 and the occurrence of acute renal failure requiring renal replacement therapy during the intensive care stay.

Key facts

Study ID

NCT07438015

Run by

Centre Hospitalier Universitaire de Besancon

People needed

525

Starts

2026-03-01

Expected to finish

2026-10-01

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients admitted to medical intensive care at Besançon Teaching Hospital for any reason.
• Aged over 18.
• Affiliated with a French social security scheme or beneficiary of such a scheme.
• No objection to participating in the study.
• Non-inclusion criteria :
• Minors
• Pregnant women and breastfeeding mothers
• Persons deprived of their liberty by judicial or administrative decision; persons undergoing compulsory psychiatric treatment; persons admitted to a health or social care institution for purposes other than research
• Adults subject to legal protection measures or unable to give their consent
• Subjects who are excluded from another study or listed in the 'national volunteer registry'.

You may not qualify if…

• Portal vein, suprahepatic or femoral vein thrombosis at the time of ultrasound examination.

Where it is running

• Centre Hospitalier Universitaire Jean MINJOZ — Besançon, France

Full record on ClinicalTrials.gov

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