Evaluation of Food Additive Contributions to Obesity: Pilot Study 1
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Obesity (Disorder)
In brief
The effects of food additives on body weight in humans are largely unknown. This is a pilot cross-over double blind RCT in obese adults aimed to test the feasibility of measuring food consumption over 24 hours after one-time administration of K sorbate versus placebo after participants reduce the background consumption of related food additives.
Key facts
- Study ID
- NCT07437430
- Run by
- McMaster University
- People needed
- 20
- Starts
- 2026-02-10
- Expected to finish
- 2026-06-01
- Last updated by the study team
- 2026-02-27
Who can join
Age: 20 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males and females age 20-80; BMI 30-39 kg/m2 inclusive; willingness and ability to follow the proposed study interventions and procedures; informed consent.
You may not qualify if…
- Weight loss of ≥3% in the last 3 months; previous or planned bariatric surgery in the next 1 year; current or planned participation in any structured weight-loss programs; current or recent (within the last 6 months) use of weight-loss-inducing drugs (including GLP-1 agonists); history of frequent intermittent or continuous use of systemic steroids; excessive alcohol consumption; recent or anticipated adjustments to mood, anxiety or anti-psychotic medications; untreated bipolar disorder or attention deficit hyperactivity disorder; eating disorder or any other disorder that may lead to significant weight changes; breastfeeding, pregnancy, planned pregnancy or planned fatherhood in the next 6 months; type 1 diabetes; uncontrolled diabetes mellitus (HbA1C≥9%); diabetes requiring treatment with insulin; aversion to foods that will be served during testing sessions.
Where it is running
- McMaster University Medical Centre — Hamilton, Ontario, Canada (enrolling)
Full record on ClinicalTrials.gov
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