Optimal Time for Reperfusion in Acute Pulmonary Embolism
Recruiting now
Conditions studied: Pulmonary Embolism (Diagnosis), Pulmonary Embolism Acute
In brief
Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality worldwide. Current guidelines recommend early reperfusion for high-risk and intermediate-high-risk PE, yet systemic thrombolysis and percutaneous therapies are frequently underutilized, and no specific timing for reperfusion is defined, unlike in acute myocardial infarction or ischemic stroke. As most PE-related in-hospital deaths occur within the first hours and thrombus composition changes over time, defining an optimal reperfusion time window may improve survival and prevent hemodynamic deterioration. We therefore propose a national, multicenter, prospective observational study to evaluate the prognostic impact of reperfusion timing, using systemic thrombolysis or catheter-directed therapies, on in-hospital mortality and haemorrhagic or cardiovascular complications.
Key facts
- Study ID
- NCT07436702
- Run by
- Azienda ULSS 8 Berica
- People needed
- 500
- Starts
- 2025-11-25
- Expected to finish
- 2026-10-30
- Last updated by the study team
- 2026-03-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Patients with a diagnosis of intermediate-high or high pulmonary embolism confirmed by computed tomography pulmonary angiography (CTPA), pulmonary angiography, or echocardiography (evidence of a floating thrombus in the right atrium or right ventricle, or proximal visualization of thrombus in the pulmonary artery).
- Classified as high-risk or intermediate-high-risk according to the 2019 European Society of Cardiology guidelines.
- Provision of informed consent for the processing of personal data.
You may not qualify if…
- Age < 18 years
- Patients in whom a diagnosis of acute high-risk or intermediate-high-risk pulmonary embolism has been excluded.
- Inability to provide informed consent.
Where it is running
- UO Unità di Cure Intensive Cardiologiche e Cardiologia 1, Ospedale Niguarda, Milano — Milan, Milano, Italy (enrolling)
- UOC di Cardiologia, Ospedali Riuniti Padova Sud, Monselice, Italia — Monselice, Padova, Italy (enrolling)
- IRCCS Policlinico San Matteo — Pavia, Pavia, Italy (enrolling)
- UO di Sezione di Medicina Interna e Cardiovascolare, Ospedale Santa Maria della Misericordia, Perugia, Italia — Perugia, Perugia, Italy (enrolling)
- UO di Cardiologia 1, Azienda Ospedaliero Universitaria Pisana, Pisa, Italia — Pisa, Pisa, Italy (enrolling)
- UO di Cardiologia, Azienda Ospedaliera Ordine Mauriziano di Torino — Torino, Torino, Italy (enrolling)
- UOC di Cardiologia, Ospedali dell'Ovest Vicentino, Arzignano, IItalia — Arzignano, Vicenza, Italy (enrolling)
Full record on ClinicalTrials.gov
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