3D Virtual Resection for Predicting Lung Function in VATS

Recruiting now

Conditions studied: Non-small Cell Lung Cancer, Lung Cancer, Lung Neoplasms

In brief

This study aims to validate a novel preoperative assessment strategy using three-dimensional (3-D) computed tomography (CT) reconstruction and virtual resection simulation. The goal is to accurately predict postoperative pulmonary function in patients with non-small cell lung cancer (NSCLC) undergoing Video-Assisted Thoracoscopic Surgery (VATS) anatomical resection. Accurate prediction of postoperative lung function is crucial for patient safety. Traditional methods, such as segment counting, often lack precision because they assume all lung segments contribute equally to function, ignoring variations caused by tumors or emphysema. This study utilizes 3-D "virtual resection" to quantify the "Planned Resected Ventilated Lung Volume Fraction" (pRVLVF) before surgery. The study will recruit 60 participants divided into two groups: those undergoing lobectomy (n=30) and those undergoing segmentectomy (n=30). Participants will undergo standard thin-slice CT scans and pulmonary function tests (PFT) before surgery. Postoperatively, lung function and recovery will be tracked at 3, 6, and 12 months to develop a dynamic prediction model and evaluate the compensatory capacity of the residual lung.

Key facts

Study ID

NCT07436598

Run by

National Taiwan University Hospital

People needed

60

Starts

2026-04-07

Expected to finish

2027-06-30

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients scheduled for video-assisted thoracoscopic (VATS) lobectomy or segmentectomy at National Taiwan University Hospital or NTU Cancer Center.
• Age between 18 and 80 years.
• Patients who have signed the informed consent form agreeing to provide imaging data for 3D modeling.

You may not qualify if…

• Age younger than 18 or older than 80 years.
• Patients not scheduled for VATS lobectomy or segmentectomy.
• Patients diagnosed with Chronic Obstructive Pulmonary Disease (COPD).
• Patients unable or unwilling to sign the informed consent form.
• Vulnerable populations.

Where it is running

• National Taiwan University Cancer Center — Taipei, Taiwan (enrolling)

Full record on ClinicalTrials.gov

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