Effect of Nalbuphine Versus Fentanyl on Hemdoynamic Effects of Laryngoscopy
Recruiting now · Phase 4
Conditions studied: Laryngoscopy, Hemodynamic Changes
In brief
Participants will undergo routine pre-operative evaluation. An intravenous line will be placed in the recovery area. On arrival in the operating room, standard monitoring (blood pressure, heart rate, oxygen saturation, ECG, breathing monitor, and temperature) will be applied. A central venous catheter and an arterial line will be inserted under local anesthesia using sterile technique. Before anesthesia induction, patients will receive premedication including midazolam and an opioid pain-relief injection given slowly through the vein. General anesthesia will then be induced with etomidate. After adequate sedation, a muscle relaxant (atracurium) will be administered, and the patient will be ventilated with 100% oxygen using a face mask. The breathing tube will then be inserted and correct placement confirmed. During surgery, anesthesia will be maintained with oxygen, sevoflurane gas, and a continuous atracurium infusion. Hemodynamic parameters such as heart rate and blood pressure will be monitored throughout the peri-intubation and intraoperative period.
Key facts
- Study ID
- NCT07435337
- Run by
- Rawalpindi Institute of Cardiology
- People needed
- 98
- Starts
- 2026-02-21
- Expected to finish
- 2026-05-21
- Last updated by the study team
- 2026-02-27
Who can join
Age: 40 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Weighing 40-70kg
- ASA III of either sex
- Undergoing cardiac surgery with CPB
You may not qualify if…
- History of Drug Allergy • Pre-existing Asthma • Renal or Hepatic dysfunction • Extreme obesity • Pregnant / lactating patients • Difficult intubation/prolonged intubation
Where it is running
- Deparment of Anesthesia, Rawalpindi Institute of Cardiology, Rawalpindi — Rawalpindi, Punjab Province, Pakistan (enrolling)
Full record on ClinicalTrials.gov
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