Analysis of Inflammatory Biomarker Changes in Dry Blood Spot Versus Venous Blood Samples

Recruiting now

Conditions studied: Inflammation, Inflammation Biomarkers, Blood Sampling, Dried Blood Spot

In brief

The purpose of this study is to see whether dried blood spot (DBS) samples can measure inflammatory biomarkers as accurately as venous blood samples. Investigators will be measuring inflammatory biomarkers changes obtained in DBS compared with paired venous blood samples following a controlled physiological stressor (i.e. after a vaccine or other planned event that can cause a temporary rise in inflammation). These findings will help understand whether DBS can be a reliable alternative to traditional blood draws in future research and healthcare.

Key facts

Study ID

NCT07435285

Run by

McGill University Health Centre/Research Institute of the McGill University Health Centre

People needed

50

Starts

2026-01-15

Expected to finish

2026-12-01

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men or women aged ≥18 years, who are planning to receive a seasonal vaccine OR have a scheduled acute stressor*.

You may not qualify if…

• Any infectious symptoms (fever, cough, rhinorrhea, sore throat, diarrhea, loss of smell or taste) within the previous 7 days
• Any self-reported active/recent use of cocaine, injection drugs, or amphetamines
• Acute worsening of a known chronic health condition within the previous 30 days (e.g., of IBD, COPD, asthma, rheumatologic disease)
• Known severe allergy or intolerance to the planned vaccine
• Contraindication to the vaccine received, if applicable
• List of possible scheduled acute stressors include:
• Hard exercise (incl. 10km run or longer, high-intensity interval training, or comparable endurance activity)
• Social event with moderate alcohol consumption
• Planned change in medication dose and/or frequency of use
• Onset of menstruation (day 1)
• Other pre-planned stressors expected to elicit an inflammatory response

Where it is running

• Research Institute of the McGill University Health Centre — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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