A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)

Running, not enrolling · Phase 1

Conditions studied: Healthy

In brief

The main goals of this study are: * To learn what happens to one dose of MK-2828 in a healthy person's body over time when it is taken with itraconzole * To learn what happens to one dose of midazolam in a healthy person's body over time when it is taken with MK-2828 Researchers want to learn if the levels of MK-2828 in the body are about the same when MK-2828 is taken with itraconazole as when it is taken alone. They also want to know if taking MK-2828 more than once affects how much midazolam is in the body after a single dose.

Key facts

Study ID

NCT07435194

Run by

Merck Sharp & Dohme LLC

People needed

28

Starts

2026-03-06

Expected to finish

2026-08-12

Last updated by the study team

2026-08-06

Who can join

Age: 24 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• The main inclusion criteria include but are not limited to the following:
• Participant is in good health

You may not qualify if…

• The main exclusion criteria include but are not limited to the following:
• History of cancer (malignancy)
• History of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases

Where it is running

• Fortea CRU Madison ( Site 0001) — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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