Reference Intervals With Indirect Methods in Italy
Recruiting now
Conditions studied: Reference Intervals
In brief
Reference intervals are an essential tool for the clinical interpretation of laboratory test results. Traditionally, these interval are determined using samples from healthy individuals, a process that is resource-intensive, time-consuming, and require the active recruitment of healthy volunteers. In recent years, due to the increasing availability of electronic health record (EHR) databases and the growing number of laboratory tests, it is possible to determine the reference intervals indirectly. This approach relies on the analysis of routine data acquired in clinical laboratories, eliminating the need for active recruiting healthy subjects and significantly reducing costs. Moreover, the method has the potential to eliminate the selection bias of an ultra-healthy population typical of the direct methods. The indirect methods for determining reference intervals have evolved from simple strategies of isolating the healthy population using sample metadata, to sophisticated statistical models that effectively distinguish normal from pathological distributions. One of the advanced techniques, RefineR, has reached an excellent combination of accuracy, robustness, and computational efficiency, outperforming previous methods. It has been implemented as an open-source R package, facilitating its application in real-world settings. In recognition of these advantages, the IFCC (International Federation of Clinical Chemistry and Laboratory Medicine), through its Committee on Reference Intervals and Decision Limits (C-RIDL), has promoted the adoption of indirect methods for determining reference intervals, highlighting the advantages of this strategy, including greater speed, lower costs, and the absence of a need to recruit healthy donors. Furthermore, a recent study has highlighted age-related physiological variations in hemoglobin levels in elderly population. This underscores the need for defining age-specific reference intervals which are currently absent from most laboratory reports, potentially impacting diagnostic accuracy.
Key facts
- Study ID
- NCT07433777
- Run by
- Centro di Riferimento Oncologico - Aviano
- People needed
- 1000000
- Starts
- 2025-10-08
- Expected to finish
- 2028-06-01
- Last updated by the study team
- 2026-02-25
Who can join
Age: any, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- no one
You may not qualify if…
- no one
Where it is running
- Centro di Riferimento Oncolgico -IRCCS — Aviano, Pordenone, Italy (enrolling)
- Azienda Ospedaliero-Universitaria Ospedali Riuniti di Ancona — Ancona, Ancona, Italy
- Azienda USL Toscana Sud Est, Arezzo — Arezzo, Arezzo, Italy
- Azienda ULSS 1 Dolomiti — Belluno, Belluno, Italy
- Azienda Ospedaliero-Universitaria Careggi, Firenze — Florence, Firenze, Italy
- IRCCS Istituto Clinico Humanitas, Milano — Milan, Milano, Italy
- IRCCS Ospedale San Raffaele, Milano — Milan, Milano, Italy
- Azienda Ospedaliero-Universitaria di Modena — Modena, Modena, Italy
- Bianalisi Carate Brianza, Monza e Brianza — Monza, Monza, Italy
- Azienda Ospedaliero-Universitaria Maggiore della Carità di Novara — Novara, Novara, Italy
- Azienda Ospedale Università Padova — Padova, Padova, Italy
- Azienda Ospedaliera Universitaria Policlinico 'Paolo Giaccone' di Palermo — Palermo, Palermo, Italy
- Azienda Sanitaria Friuli Occidentale, Ospedale di Pordenone — Pordenone, Pordenone, Italy
- Azienda Ospedaliera Universitaria Senese, — Siena, Siena, Italy
- Azienda Sanitaria Universitaria Giuliano Isontina — Trieste, Trieste, Italy
- Azienda Sanitaria Universitaria Friuli Centrale, Ospedale di Udine — Udine, Udine, Italy
- AULSS 3 Serenissima, Ospedale di Mestre — Mestre, Venezia, Italy
- Azienda Ospedaliera Universitaria Integrata di Verona — Verona, Verona, Italy
- AULSS 8 Berica, Ospedale S. Bortolo di Vicenza — Vicenza, Vicenza, Italy
- Ospedale di Desio, ASST Brianza — Desio, Italy
- ASL5 Spezzino, La Spezia — La Spezia, Italy
- ASST Grande Ospedale Metropolitano Niguarda, Milano — Milan, Italy
- ASL Bari, Ospedale della Murgia, Altamura — Altamura, Altamura, Italy
- Azienda ULSS 2 Marca Trevigiana — Treviso, Italy
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.