Impact of Supplementation in Improving Metabolic Health Outcomes (ISMOS) Study
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Glucose Control, Mental Health, Musculoskeletal Health, Body Composition
In brief
This study investigates the role of multivitamin and multimineral (MVM) supplementation in improving metabolic, musculoskeletal, and mental health among midlife Asian women aged 40-60 years, a critical period marked by hormonal and physiological transitions from pre- to post-menopause. Evidence from the GUSTO cohort in Singapore has shown that higher plasma levels of vitamins B6, B9, B12, and D are associated with better metabolic profiles, insulin sensitivity, and mental wellbeing, while deficiencies are linked to increased metabolic and psychological risks. Given that vitamin insufficiency and central obesity are highly prevalent among Asian women even at lower BMI, this randomized, double-blind, placebo-controlled trial will evaluate whether 12 months of daily MVM supplementation can reduce MetaboAge and improve metabolic, mental, and muscle health outcomes compared with placebo. Findings will inform preventive strategies for extending health span and mitigating chronic disease risks among midlife women in Asia.
Key facts
- Study ID
- NCT07433049
- Run by
- Institute for Human Development and Potential (IHDP), Singapore
- People needed
- 400
- Starts
- 2026-01-20
- Expected to finish
- 2028-01-01
- Last updated by the study team
- 2026-02-25
Who can join
Age: 40 and older, up to 60. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Women aged 40-60 years old
- Chinese, Malay or Indian
- BMI between 23.0-35.0 kg/m2
- Proficient in English language
- Willing to comply with study protocol \& provide informed consent
You may not qualify if…
- Pregnant or planning a pregnancy
- Diagnosis with Diabetes, Polycystic Ovary Syndrome (PCOS), autoimmune diseases, chronic organ failure, severe heart disease, eating disorders and/or other medical conditions which in the PI's judgment which may affect study outcomes
- Fasting glucose value ≥ 7.0 mmol/L
- Active cancer or treatment of cancer in the last 3 years
- Participating in other nutritional intervention studies
- Taking oral corticosteroids, anti-psychotic and/or weight loss drugs
- Having planned hospitalization in the next 12 months
- Planning to have major diet changes in the next 12 months
- Taking a medically prescribed supplement(s) that contains 3 or more of the ingredients of the study product
- Taking a non-prescribed supplement(s) that contains 3 or more of the ingredients of the study product in the last 1 month
Where it is running
- Institute for Human Development and Potential (IHDP) — Singapore, Singapore (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.