Kinematics-Based Prediction of Chronic Pain After Combat-Related Extremity Trauma
Enrolling by invitation
Conditions studied: Residual Limb Pain, Post-Traumatic Limb Pain, Extremity Trauma, Combat-Related Limb Injury, Phantom Limb Pain, Phantom Limb Pain After Amputation, Chronic Pain Due to Injury, Chronic Pain
In brief
Combat-related extremity trauma frequently results in persistent pain, including neuropathic, residual limb, and phantom limb pain. The kinematics of injury-including energy level, direction of force, and dominant force components-may independently predict tissue deformation, nerve stress, and the transition from acute to chronic- pain. This prospective observational cohort study will assess whether kinematics-only variables predict chronic pain outcomes after combat-related upper and lower limb injuries. Pain outcomes will include pain intensity, pain extent (surface/area), neuropathic pain features, and mechanical pain sensitivity measured using von Frey filaments.
Key facts
- Study ID
- NCT07432685
- Run by
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
- People needed
- 100
- Starts
- 2026-03-12
- Expected to finish
- 2027-12-14
- Last updated by the study team
- 2026-02-25
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥18 years
- Combat-related extremity trauma involving upper and/or lower limbs
- Blunt limb trauma
- Penetrating limb injury (ballistic or shrapnel)
- Blast-related limb injury
- Hybrid injury (blast plus fragment)
- тTraumatic amputation (partial or complete)
- Baseline assessment performed within 72 hours of injury
- Acute limb pain with Numeric Rating Scale (NRS) score ≥3 at baseline
- Ability to provide informed consent
- Ability to participate in follow-up assessments
You may not qualify if…
- Inability to complete follow-up assessments
- Severe cognitive impairment preventing informed consent
- Declines participation
Where it is running
- Superhumans War Trauma Center — Lviv, Ukraine
Full record on ClinicalTrials.gov
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