Testing a Mobile Health Application to Improve HIV Prevention and Substance Use Treatment Among Women Involved in the Carceral System

Starting soon · Not applicable

Conditions studied: Substance Abuse, HIV

In brief

Women involved in the carceral system (WICS) are at higher risk for both HIV and substance use than the general public. WICS are also more likely to engage in behaviors both before and after release that put them at risk for HIV and for overdose, due to opioid use. Despite these risk factors, WICS are less likely to be aware of, use, or adhere to pre-exposure prophylaxis (PrEP) and have less access to medications for opioid use disorder (MOUD). The primary goal of the proposed research is to pilot test a systematically developed PrEP and MOUD uptake intervention for WICS using contextually relevant messages developed through novel formative research methods and embedded in a web-based application in a rigorous research design. The investigators will then test this approach (called PA-LINKS) in a pilot randomized trial with women who have recently been incarcerated in Philadelphia in partnership with Philadelphia FIGHT, a federally qualified health center, for promise of efficacy, and to assess feasibility and acceptability.

Key facts

Study ID

NCT07432555

Run by

Temple University

People needed

74

Starts

2026-08-01

Expected to finish

2026-08-30

Last updated by the study team

2026-05-13

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• 18 of years of age or older
• Self-identified woman
• Previous experience (past six months) with the carceral system (jail, prison, on parole or under supervision)
• Speaks and reads English
• Self-reported negative HIV status
• Indicates at least one HIV risk (i.e. any of the following in the past 6 months or in the six months prior to the most recent incarceration that call for consideration of PrEP as per the CDC risk indices: have engaged in condomless sex; have an HIV-positive sex partner; have had an STI; have had multiple [>6] partners; have engaged in transactional sex; have injected drugs, shared injection or drug use preparation equipment, or have been enrolled in opiate substitution therapy because of IDU; previous overdose)
• Self-report using opioids in the past six months or six months prior to the most recent incarceration (prescription or not) OR self-report using medications for opioid use disorder in the past year.
• Have access to the internet through some device - smart phone, computer or tablet (personal or at community location such as library or organization)

You may not qualify if…

• Under 18 years old
• Does not read or speak English
• Does not identify as a woman
• Has been diagnosed with HIV
• Does not have previous experience with the criminal legal system within the last 6 months
• Does not have HIV risk in last six months or six months prior to being incarcerated
• Has not used opioids in past six months or six months prior to being incarcerated or MOUD in last year
• Does not have access to internet
• Cannot provide informed consent

Where it is running

• Temple University — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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