Single-step vs Stepwise Lung Recruitment Maneuvers After Cardiopulmonary Bypass
Recruiting now · Not applicable
Conditions studied: Atelectasis, Postoperative
In brief
This prospective randomized controlled trial aims to compare the hemodynamic and pulmonary effects of single-step and stepwise lung recruitment maneuvers in adult patients undergoing elective cardiac surgery with cardiopulmonary bypass. After separation from cardiopulmonary bypass, patients will be randomized to receive either a single-step sustained inflation recruitment maneuver or a stepwise incremental recruitment maneuver, both combined with 8 cmH₂O positive end-expiratory pressure. The primary outcome is the change in cardiac index before and after the recruitment maneuver. Secondary outcomes include lung ultrasound atelectasis score, and hemodynamic parameters.
Key facts
- Study ID
- NCT07432477
- Run by
- Ondokuz Mayıs University
- People needed
- 52
- Starts
- 2026-02-15
- Expected to finish
- 2027-05-01
- Last updated by the study team
- 2026-07-01
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-80 years
- ASA (American Society of Anesthesiologists) II-IV
- Patients undergoing elective cardiac surgery (coronary artery bypass grafting, mitral valve replacement, aortic valve replacement)
You may not qualify if…
- Emergency surgery
- Presence of perioperative arrhythmia
- <35% left ventricular ejection fraction
- >50 mmHg systolic pulmonary artery pressure
- Known chronic obstructive pulmonary disease or interstitial lung disease
- Pneumothorax
- Mean arterial pressure <60 mmHg during recruitment maneuver
- New York Heart Association (NYHA) class III-IV heart failure
- Advanced cardiomyopathy or severe mitral regurgitation
- Cross-clamp time longer than 2 hours
- Requirement for high-dose inotropic or vasopressor support
- Patients who cannot be extubated after postoperative 24 hours
Where it is running
- Ondokuz Mayıs University, Faculty of Medicine — Samsun, Turkey (Türkiye) (enrolling)
Full record on ClinicalTrials.gov
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