Methotrexate Versus Apremilast for Pruritus in Psoriasis

Starting soon · Phase 4

Conditions studied: Psoriasis, Pruritus

In brief

This randomized controlled trial aims to compare the efficacy of Methotrexate versus Apremilast in reducing pruritus and improving quality of life in patients with psoriasis. Eighty patients aged 20 to 60 years with psoriasis involving more than 8% body surface area and associated pruritus will be enrolled and randomly assigned into two groups. Group A will receive oral Apremilast titrated to 30 mg twice daily, while Group B will receive oral Methotrexate 10 mg once weekly for 8 weeks. The primary outcome will be change in Dermatology Life Quality Index (DLQI) score at 8 weeks. Secondary outcomes include change in numerical rating scale for pruritus and assessment of adverse effects. The study will be conducted at Pakistan Emirates Military Hospital Rawalpindi.

Key facts

Study ID

NCT07432386

Run by

Zarmeen Khawar

People needed

80

Starts

2026-05-14

Expected to finish

2026-10-14

Last updated by the study team

2026-05-15

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male and female patients aged 18 to 65 years.
• Clinically diagnosed cases of psoriasis.
• Patients experiencing pruritus associated with psoriasis.
• Patients willing to participate and provide written informed consent.
• Patients able to comply with study protocol and follow-up visits.

You may not qualify if…

• - Pregnant or lactating women.
• Patients with severe hepatic or renal impairment.
• Patients with known hypersensitivity to Methotrexate or Apremilast.
• Patients currently receiving systemic therapy for psoriasis within the last 4 weeks.
• Patients with active infections, including tuberculosis.
• Patients with malignancy.
• Patients with significant hematological abnormalities.
• Patients unwilling to provide informed consent.

Where it is running

• Pak Emirates Military Hospital — Rawalpindi, Punjab Province, Pakistan

Full record on ClinicalTrials.gov

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