Non-Invasive Dynamic Monitoring-Guided Oscillation and Lung Expansion for Airway Clearance in Severe Blunt Chest Trauma: A Clinical Study

Starting soon

Conditions studied: Blunt Chest Trauma

In brief

In our previous study, the investigators analyzed more than 30,000 cases from the National Trauma Center Database and found that 66.4% of patients with severe blunt chest trauma had concurrent rib fractures, 55.87% had multiple fractures (≥4 ribs), and 37.4% had combined pulmonary contusion. In a further prospective observational cohort study evaluating the efficacy of EIT-guided OLE in such patients, results demonstrated that this protocol improved the ventilation-perfusion ratio and oxygenation index and shortened total mechanical ventilation duration. Based on literature review and preliminary findings, the investigators propose the following hypothesis: the application of EIT-noninvasively monitored OLE airway clearance in patients with severe blunt chest trauma can improve the ventilation-perfusion ratio, shorten mechanical ventilation time, reduce the incidence of complications such as pulmonary infection and mortality, and decrease medical resource consumption. This study will verify this hypothesis through a prospective randomized controlled trial and further refine the specific implementation protocol of OLE to enhance its scientific validity and clinical applicability.

Key facts

Study ID

NCT07432048

Run by

Peking University People's Hospital

People needed

80

Starts

2026-03-01

Expected to finish

2027-11-01

Last updated by the study team

2026-02-25

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Severe blunt chest trauma, defined as injury caused by blunt force such as chest impact or compression, with an Abbreviated Injury Scale (AIS) score of the chest ≥ 3
• Age 18 to 70 years
• Time from injury to enrollment < 48 hours
• Receiving invasive mechanical ventilation, with duration of mechanical ventilation < 24 hours
• Written informed consent signed by the patient or his/her legal representative

You may not qualify if…

• Combined penetrating chest trauma
• Perinatal women
• Inability of the patient to cooperate with examinations and treatment
• Contraindications to EIT monitoring, including implanted cardiac pacemaker, unhealed local skin wound after thoracic surgery, extensive subcutaneous emphysema of the chest, etc
• Contraindications to OLE therapy:
• Hemodynamic instability (heart rate < 60 beats/min or > 130 beats/min; systolic blood pressure < 90 mmHg or > 180 mmHg; or mean arterial pressure < 60 mmHg or > 100 mmHg)
• Unstable angina pectoris or cardiac arrhythmia
• Intracranial pressure > 20 mmHg
• Active bleeding
• Suspected or active hemoptysis
• Undrained pneumothorax
• Unstable deep vein thrombosis or pulmonary embolism
• Unstable spinal or long bone fractures
• Unstable head and neck injury

Full record on ClinicalTrials.gov

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