A Study to Learn About mRNA Vaccines Against Influenza in Adults

Recruiting now · Phase 2

Conditions studied: Healthy Adults

In brief

The purpose of this study is to learn about safety in participants taking the study vaccine (mRNA-based vaccine) and the ability of the study vaccine to trigger the body's immune response, targeting the flu virus (influenza virus). This study is seeking healthy participants 18 years of age or older. All participants in this study will receive only 1 dose in their arm, to deliver one of the experimental flu vaccines or one of the approved flu vaccines used for comparison. Participants will take part in this study for about 6 months, and participants will need to visit the study site at least 3 times. A blood sample will be taken at each of the 3 planned study visits and a swab from inside the nose will be taken at the first study visit.

Key facts

Study ID

NCT07431853

Run by

Pfizer

People needed

770

Starts

2026-02-23

Expected to finish

2027-06-22

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy and medically stable participants who are determined by medical history, physical examination (if clinically required), and clinical judgment of the investigator to be eligible for inclusion in the study.

You may not qualify if…

• Tested positive for influenza ≤5 months (150 days) prior to Visit 1 (Day 1).
• Vaccination with any investigational or licensed influenza vaccine ≤5 months (150 days) before Visit 1 (Day 1).
• Receipt of antiviral therapies for influenza (eg, Tamiflu) ≤5 months (150 days) prior to Visit 1 (Day 1).

Where it is running

• AMR Clinical — Mobile, Alabama, United States (enrolling)
• Diablo Clinical Research, LLC d/b/a Flourish Research — Walnut Creek, California, United States (enrolling)
• Clinical Research Consulting, LLC — Milford, Connecticut, United States (enrolling)
• George Washington Medical Faculty Associates — Washington D.C., District of Columbia, United States (enrolling)
• Indago Research & Health Center, Inc — Hialeah, Florida, United States (enrolling)
• Palm Springs Community Health Center — Miami Lakes, Florida, United States (enrolling)
• Clinical Research Atlanta — Stockbridge, Georgia, United States (enrolling)
• East-West Medical Research Institute — Honolulu, Hawaii, United States (enrolling)
• AMR Clinical — Kansas City, Missouri, United States (enrolling)
• Rochester Clinical Research, LLC — Rochester, New York, United States (enrolling)
• DM Clinical Research - Philadelphia — Philadelphia, Pennsylvania, United States (enrolling)
• SMS Clinical Research LLC — Mesquite, Texas, United States (enrolling)
• DM Clinical Research — Tomball, Texas, United States (enrolling)
• J. Lewis Research, Inc. / Foothill Family Clinic — Salt Lake City, Utah, United States (enrolling)
• Charlottesville Medical Research Center, LLC — Charlottesville, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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