Topical Carboxytherapy Paste Following Microneedling

Starting soon · Phase 1/Phase 2

Conditions studied: Skin

In brief

Topical carboxytherapy refers to a gel paste that carries non-gaseous carbon dioxide (CO2). It is applied similarly to a face mask. Topical carboxytherapy has been shown to increase local blood flow and can help with wound healing. Few studies have researched how topical carboxytherapy can be used to aid skin rejuvenation in the field of facial plastic and reconstructive surgery. The goal of this study is to evaluate how topical carboxytherapy can improve skin healing after microneedling. Common temporary side effects of microneedling include redness and swelling, sometimes lasting up to a week post-procedure. If topical carboxytherapy reduces downtime related to side effects of microneedling, the investigators may offer this treatment to more microneedling patients in the future.

Key facts

Study ID

NCT07431541

Run by

Vanderbilt University Medical Center

People needed

20

Starts

2026-07-01

Expected to finish

2027-06-30

Last updated by the study team

2026-04-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• English-speaking adults at least 18 years of age who elect to undergo microneedling for facial aging.

You may not qualify if…

• Age under 18
• Pregnant patients
• Patients with other known medical conditions which affect facial cosmesis
• Patients who have recently undergone surgery to the facial region or minimally invasive facial procedures within the past month

Full record on ClinicalTrials.gov

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