The Effect of Muscle Stimulation and Amino Acid Intake on Protein Metabolism During Critical Illness
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Muscle Wasting in Critically Ill
In brief
The goal of this clinical trial is to study how whole-body electrical stimulation combined with amino acid intake affects muscle health in ventilated ICU patients. The main questions to answer are: * Does electrostimulation improve the balance of muscle protein in ICU patients? * Does combining electrostimulation with amino acid help build muscle and prevent muscle loss? Researchers will compare three groups of patients: 1. Sham electrostimulation (no current applied) + the standard nutrition 2. Electrostimulation + the standard nutrition 3. Electrostimulation + a 20g amino acid bolus Participants will: * Receive either real or sham electrostimulation * Get their standard nutrition or a 20g amino acid bolus * Have marked amino acids given through an IV * Have blood samples taken to measure the amino acids and glucose in the blood * Undergo ultrasound of the upper arm to measure the blood flow
Key facts
- Study ID
- NCT07430969
- Run by
- Wageningen University
- People needed
- 30
- Starts
- 2026-07-18
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-07-02
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged ≥18 years
- Expected to need mechanical ventilation for at least 48 hours, judged by physician
- Expected to reach a Richmond Agitation-Sedation Scale (RASS) score of -4 or -5 (complete sedation), judged by physician
- Informed consent obtained from the next-of-kin
- Able to or are receiving gastric tube feeding
- Have an arterial and a venous line in situ
You may not qualify if…
- Spinal cord injury
- Previous surgery/local wounds that prohibit whole-body NMES
- Conditions that prohibit NMES (such open wounds)
- Chronic neuromuscular disorders (such as Amyotrophic lateral sclerosis (ALS))
- Acute Kidney Injury (AKI) II and III
- Undergoing continuous veno-venous hemofiltration (CVVH)
- Rhabdomyolysis
- Neuromuscular blocking agents
- In the caloric restriction period of refeeding syndrome
- In prone position
- Burn wounds
- ICD/pacemaker
- Pregnant
- Deemed not suitable to participate based upon the judgement of the treating intensivist
Where it is running
- Hospital Gelderse Vallei — Ede, Netherlands (enrolling)
Full record on ClinicalTrials.gov
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