Exercise and Carotid Artery Function in Metabolic Syndrome
Recruiting now
Conditions studied: Metabolic Syndrome
In brief
The purpose of this study is to determine 1) if young adults with metabolic syndrome display endothelial dysfunction of the internal carotid artery in a sex-specific fashion and 2) if this endothelial dysfunction can be acutely improved with a single bout of exercise. This will be achieved by testing internal carotid artery function before and after a 30-minute bout of moderate intensity exercise. 48 young adults with and without metabolic syndrome will be enrolled and will be on study for approximately 5.5 hours over 4 study visits.
Key facts
- Study ID
- NCT07430839
- Run by
- University of Wisconsin, Madison
- People needed
- 48
- Starts
- 2025-12-01
- Expected to finish
- 2027-06-30
- Last updated by the study team
- 2026-03-25
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Current smoker, defined as more than 5 cigarettes over past 30 days
- Current diagnosis or history of:
- peripheral vascular disease
- hepatic disease
- renal disease
- lung disease
- gastrointestinal disorders/bleeding
- hematologic disease
- stroke
- myocardial infarction
- coronary heart disease
- congestive heart failure
- heart surgery
- sleep apnea
- autoimmune diseases
- traumatic brain injury, concussion, stroke, or seizures
- Asthma
- Polycystic ovarian syndrome
- Type II diabetes
- Currently pregnant or breastfeeding
- Current musculoskeletal injury Medication use known to influence cardiovascular function, other than oral contraceptives
- Hormonal contraceptive use, such as intrauterine device or hormonal implant use
- Participants with ICAs unsuitable for imaging, as assessed during the screening visit via doppler ultrasonography
- Exclusion Criteria (healthy controls only):
- BMI greater than 25 kg/m2
Where it is running
- University of Wisconsin — Madison, Wisconsin, United States (enrolling)
Full record on ClinicalTrials.gov
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