Synbiotic Supplementation and Inflammation in Predialysis Chronic Kidney Disease

Starting soon · Not applicable · Has a placebo group

Conditions studied: Chronic Kidney Disease, Inflammation

In brief

Chronic kidney disease (CKD) is a long-term condition in which the kidneys gradually lose their ability to function properly. People with chronic kidney disease (CKD) often experience chronic inflammation and digestive symptoms that may affect their quality of life. This study aims to evaluate whether daily supplementation with a synbiotic (a combination of probiotics and prebiotics) can reduce inflammation and improve gastrointestinal symptoms in adults with chronic kidney disease (CKD) stages 3 to 5 who are not receiving dialysis. Participants will be randomly assigned to receive either a synbiotic containing Lactobacillus rhamnosus, Bifidobacterium longum, and agave fructans, or a placebo, for a total of 16 weeks. Blood tests will be performed to measure inflammation, and participants will complete questionnaires related to digestive symptoms, quality of life, and dietary habits. The information obtained from this study may help improve nutritional strategies and supportive care for people living with chronic kidney disease.

Key facts

Study ID

NCT07430280

Run by

Centenario Hospital Miguel Hidalgo

People needed

100

Starts

2026-03-01

Expected to finish

2026-06-01

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 to 80 years.
• Diagnosis of chronic kidney disease in pre-dialysis stages.
• Stable clinical condition for at least 3 months prior to enrollment.
• Ability to provide written informed consent.

You may not qualify if…

• Current renal replacement therapy (hemodialysis or peritoneal dialysis).
• Acute kidney injury.
• Use of antibiotics, probiotics, prebiotics, or synbiotics within 4 weeks prior to enrollment.
• Active infection, inflammatory disease, or malignancy.
• Pregnancy or breastfeeding
• Known intolerance or allergy to components of the synbiotic or placebo.

Full record on ClinicalTrials.gov

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