Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia

Starting soon

Conditions studied: Pre-Eclampsia, Severe, Pregnancy

In brief

The goal of this observational study is to determine whether noninvasive finger plethysmographic cardiac output monitoring can help predict fluid responsiveness in pregnant women, including those with preeclampsia with severe features. The main questions it aims to answer are : * Can changes in cardiac output measured by finger plethysmography predict fluid responsiveness? * How does this method perform compared with standard echocardiographic assessment? Participants will provide consent and undergo noninvasive hemodynamic monitoring and a brief reversible physiological challenge.

Key facts

Study ID

NCT07430254

Run by

Stanford University

People needed

88

Starts

2026-07-01

Expected to finish

2028-07-01

Last updated by the study team

2026-02-24

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women diagnosed with preeclampsia with severe features following ACOG recommendations (systolic/diastolic BP >160/110 mmHg, proteinuria, or other severe features like headaches, visual disturbances, kidney/liver impairment, thrombocytopenia).
• Healthy pregnant women at term (for comparison group, e.g., scheduled for elective Cesarean delivery).

You may not qualify if…

• Patients who can not provide written consent to participate in the study
• BMI greater than 40 kg/m²
• Multiple pregnancy (twins, triplets, etc.)
• Non-reassuring fetal heart tracing
• ≤ 22 weeks gestation
• History of chronic arterial hypertension
• Chronic kidney disease
• Congenital or known acquired heart disease
• Chronic obstructive pulmonary disease
• Diabetes
• History of stroke
• Not tolerating passive leg raising (unable to be placed in the required study position)
• No TTE-windows
• Withdrawing consent
• Emergency cesarean delivery

Where it is running

• Lucile Packard Children's Hospital — Palo Alto, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.