Screw-Integrated vs Traditional Cervical Cages in ACDF for Degenerative Disc Disease
Starting soon · Not applicable
Conditions studied: Cervical Cage With Screw, Cervical Degenerative Disc Disease, Anterior Cervical Discectomy and Fusion (ACDF)
In brief
This study is a prospective, comparative clinical trial conducted at Assiut University Hospitals to evaluate the effectiveness of two different interbody fusion devices in patients with Cervical Degenerative Disc Disease (CDDD). The primary objective is to compare cervical cages with integrated screws against traditional stand-alone cervical cages during single or double-level Anterior Cervical Discectomy and Fusion (ACDF). While ACDF is the gold standard for CDDD, traditional cages can sometimes lead to complications like subsidence or incomplete fusion; integrated screw designs aim to provide immediate stability and reduce these risks. Investigators will assess 40 patients over a 12-month follow-up period, focusing on primary outcomes of radiological interbody fusion using the Daniel Riew grading system. Secondary outcomes include the maintenance of cervical alignment (Ishihara Index), change in segmental angles (Cobb's method), disc height restoration, and clinical improvements in pain and function measured by the Visual Analog Scale (VAS) and Neck Disability Index (NDI). The study's rationale is to provide clearer evidence on whether screw-integrated cages offer superior radiological and clinical outcomes to help guide future surgical preferences
Key facts
- Study ID
- NCT07430163
- Run by
- Assiut University
- People needed
- 40
- Starts
- 2026-03-15
- Expected to finish
- 2027-12-30
- Last updated by the study team
- 2026-02-24
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients aged above 18 years old.
- Clinical diagnosis of cervical degenerative disc disease (CDDD).
- Single or double level cervical degenerative disc disease (CDDD) confirmed by MRI
- Failure of conservative treatment for at least 6 weeks.
- Patients indicated for Anterior Cervical Discectomy and Fusion (ACDF).
- Availability of complete preoperative and postoperative clinical and radiological data.
- Willing and able to provide informed consent.
You may not qualify if…
- Previous cervical spine surgery.
- Mutli-level (more than double level) cervical degenerative disc disease (CDDD).
- Significant cervical instability requiring additional posterior fixation
- Cervical trauma, fracture, or spinal infection.
- Cervical tumors or inflammatory spinal disease.
- Severe cervical deformity (fixed kyphosis)
- Osteoporosis or metabolic bone disease.
- Pregnancy
- Psychiatric illness or substance abuse that would compromise follow-up
Full record on ClinicalTrials.gov
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