Post-Operative Pain Relief: Zynrelef or Periarticular Injections in RATKA

Starting soon · Phase 4

Conditions studied: Periarticular Block, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee, Pain After Surgery, Knee Arthroplasty, Total

In brief

Prospective Cohort of patients who are scheduled for a Robot Assisted Total Knee Arthroplasty (RATKA). A prospective survey of patient reported outcome measures (Numeric Rating Scale) will be obtained postoperatively of 72 hours, as well as at the postoperative opioid consumption after 72 hours.

Key facts

Study ID

NCT07430085

Run by

Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)

People needed

150

Starts

2026-07-31

Expected to finish

2028-02-28

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females aged 18-89 years
• Diagnosed with knee osteoarthritis requiring surgical intervention
• Indicated for unilateral RATKA

You may not qualify if…

• Pediatric, pregnant, or incarcerated patients
• BMI of more than 45 kg/m2
• Prolonged opioid use history of >5 mg/day for >1 month
• History of contralateral TKA <2 years prior to the index TKA
• Type 1 Hypersensitivity to NSAIDs or local anesthetics
• Diagnosis of severe renal disease

Full record on ClinicalTrials.gov

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