Evaluation of Efficacy and Tolerabilty of MelaB3 Serum in Combination of 35% Glycolic Acid Peeling Compared to 35% Glycolic Acid Peeling Alone in Various Hyperpigmentation Conditions

Starting soon · Not applicable

Conditions studied: Hyperpigmentation, Melasma, Solar Lentigo, Peeling

In brief

Randomized clinical trial to assess the effectiveness and tolerability of Mela B3 serum in combination with 35% glycolic acid peel vs. 35% glycolic acid peel for the treatment of various hyperpigmentation conditions (melasma, post-inflammatory hyperpigmentation and solar lentigo) and signs of aging in a population of participants from the Autonomous City of Buenos Aires, Argentina.

Key facts

Study ID

NCT07429786

Run by

Cosmetique Active International

People needed

80

Starts

2026-03-04

Expected to finish

2026-06-01

Last updated by the study team

2026-02-24

Who can join

Age: 30 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Women and men
• From 30 to 70 years of age (inclusive)
• Good general health
• With any type of phototype
• Hyperpigmentation condition with average darkness > 3:
• Epidermal or mixed melasma (determined by Wood's lamp examination at screening), mild to moderate melasma (IGA 1 or 2)
• Post acne inflammatory hyperpigmentation (PIHP), mild to moderate (IGA 1 or 2) with no active acne and less than 10 inflammatory lesion on full face
• Solar lentigo (SL) with a pigmentation score>5
• Willingness to protect oneself from the sun as much as possible for the duration of the study
• Willingness to avoid contraindicated products (irritants, other depigmenting agents)
• Signing of written informed consent

You may not qualify if…

• Pregnant, breastfeeding or with pregnancy plans.
• All contraindications for superficial peeling (for example, concomitant infectious processes or inflammatory processes that affect the skin barrier).
• Melasma with predominance of the pigmentary component at the dermis level, observed with Wood's light at the inclusion visit.
• Active acne with 10 or more inflammatory lesions.
• In the case of melasma, participants with recent change of contraception (less than 3 months) or less than 3 months since childbirth.
• Participant using irritating products (require a washout period of at least 2 weeks).
• Use of medications that may induce melasma, such as antiepileptics (requires a washout period of 1 month).
• Use of other products with depigmenting activity (requires a washout period of 1 month).
• Other facial dermatoses or known photosensitivity, or a pre-existing or latent dermatologic health condition and/or disease on the face (e.g., psoriasis, rosacea, acne, eczema, seborrheic dermatitis, severe excoriations) that, in the judgment of the investigator, are considered inappropriate for participation or may interfere with study results.
• Topical treatments applied to the face (requires a 2-week washout period).
• Scheduled facial procedures during the course of the study.
• Participants undergoing phototherapy (requires a 1-month washout period).
• Known hypersensitivity to study products.
• History of laser resurfacing procedures, intense pulsed light, facial radiofrequency, deep peeling, facial mesotherapy with tranexamic acid, botulinum toxin or dermal filler injections, or cosmetic procedures on the face within 6 months prior to the start of the study.
• Facial treatment with microdermabrasion within 6 weeks prior to study entry.
• Persons with visible tanning, scars, moles, excessive hair or other dermal conditions on the face that, in the judgment of the investigator, may influence the results of the study.
• History of skin cancer, immunosuppression or immunodeficiency disorders (including HIV infection or AIDS), or current use of immunosuppressive drugs.
• Uncontrolled disease such as asthma, diabetes, hypertension, hyperthyroidism or hypothyroidism. Persons with multiple health conditions may be excluded, even if controlled by diet or medication.
• Participation in another clinical trial within one week prior to entering this study.

Full record on ClinicalTrials.gov

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