Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy

Recruiting now · Phase 1

Conditions studied: Appendectomy

In brief

To compare the clinical outcomes of intraperitoneal bupivacaine instillation vs placebo as preemptive analgesia in patients undergoing open appendectomy

Key facts

Study ID

NCT07429448

Run by

Sardar Umer Rehman

People needed

60

Starts

2025-12-16

Expected to finish

2026-06-16

Last updated by the study team

2026-02-24

Who can join

Age: 20 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients presenting to the emergency department undergoing open appendectomy.

You may not qualify if…

• Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness/ fever) and USG findings (presence of abscess, fluid collection, or free air).
• Uncontrolled medical disease (DM: BSL >200mg/dl, HTN: BP >140/90)
• History of chronic kidney or liver disease/ psychiatric illness/ Active peptic ulcer disease (as determined on history and medical records)
• Alcoholics
• History of chronic pain or patients on analgesic medications
• Pregnant females
• History of allergy to bupivacaine/ ketorolac as determined on history
• Children, Adolescents and patients with mental illness.

Where it is running

• Services Institute of Medical Sciences/ Services Hospital Lahore — Lahore, Punjab Province, Pakistan (enrolling)

Full record on ClinicalTrials.gov

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