Data-Driven Phenotyping in Heart Failure With Preserved Ejection Fraction

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Conditions studied: Heart Failure, Heart Failure, Diastolic, Heart Failure With Preserved Ejection Fraction (HFPEF)

In brief

The goal of this observational study is to learn how people with Heart Failure with Preserved Ejection Fraction (HFpEF) can be grouped into different "phenotypes" based on their clinical information. The researchers want to understand whether these groups have different health profiles and different responses during a cardiopulmonary exercise test (CPET). The main questions this study aims to answer are: * Can clinical data be used to identify meaningful HFpEF phenotypes? * Do these phenotypes match well-known HFpEF scores, such as the H2FPEF and Heart Failure Association Pre-test Assessment, Echocardiography and Natriuretic Peptide (HFA-PEFF) scores? * Do people in different phenotypes show different results on a CPET? Participants will: * Have their past clinical records reviewed if they were diagnosed with HFpEF at the Local Health Unit of the Leiria Region (ULS RL); * A smaller group will attend one visit to complete a CPET, which measures how the heart, lungs and muscles respond during exercise. This study includes adults aged 18 years or older who have HFpEF. The study does not involve any new treatments or experimental drugs.

Key facts

Study ID

NCT07429396

Run by

Instituto Politécnico de Leiria

People needed

200

Starts

2026-12-01

Expected to finish

2028-05-31

Last updated by the study team

2026-02-24

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Retropective observational phase (Phase I):
• Age ≥18 years;
• Established diagnosis of heart failure with preserved ejection fraction (LVEF ≥50%);
• Patients receiving care (outpatient or inpatient) at the Local Health Unit of the Leiria Region (ULS RL) since September 2018.
• Cross-sectional observational phase (Phase II - CPET):
• Age ≥18 years;
• Established diagnosis of HFpEF;
• Selection as a volunteer representative of phenotypes identified in the retrospective clustering analysis;
• Provision of written informed consent prior to any study-specific procedures.

You may not qualify if…

• Retropective observational phase (Phase I):
• Incomplete or inadequate medical records preventing full data extraction.
• Cross-sectional observational phase (Phase II - CPET):
• Medical contraindication or physical inability to perform cardiopulmonary exercise testing (CPET);
• Inability to provide informed consent.

Where it is running

• Local Health Unit of the Leiria Region — Leiria, Leiria District, Portugal
• ciTechCare - Center for Innovative Care and Health Technology — Leiria, Portugal

Full record on ClinicalTrials.gov

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