Combined Tibial Nerve Stimulation and Standing for People With SCI

Recruiting now · Not applicable

Conditions studied: Spinal Cord Injury

In brief

The goal of this clinical trial is to understand how sensory inputs from the lower leg can influence pelvic floor muscle function and urogential function in adults with chronic spinal cord injury (SCI). The main questions it aims to answer are: 1. What is the modulatory role of load and posture on reflex activation of the pelvic floor muscles in participants with SCI? 2. What is the feasibility of combining tibial neuromodulation with standing therapy in participants with SCI? 3. What are the potential effects of combined tibial neuromodulation and standing therapy on reflex excitability and urogential symptoms and quality of life in people with SCI? Participants will be asked complete a series of assessments (questionnaires, electrophysiological testing) before and after a 12-week intervention of combined standing and tibial nerve stimulation therapy.

Key facts

Study ID

NCT07429305

Run by

University of British Columbia

People needed

12

Starts

2026-04-02

Expected to finish

2027-06-30

Last updated by the study team

2026-04-08

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• At least 19 years of age
• Have a SCI between C7 - T10 that occurred at least 12 months previously
• Have a motor-complete or incomplete SCI (AIS A, B, C, or D)
• Have symptoms of neurogenic LUT dysfunction
• Meet the manufacture requirements for standing frame use (will be evaluated by the research team)
• Are able to speak and understand English.

You may not qualify if…

• Have changed their bladder management program in the past month
• Have received an injection of Botulinum toxin-A in any LUT structure in the past 2 weeks, or intend to receive an injection while participating in the trial
• Have a non-stable SCI (e.g. spinal tumor)
• Have signs of a lower motoneuron injury (e.g. cauda equina syndrome)
• Have other neurological injury besides SCI
• Have an implanted metallic or electronic device (e.g. pace maker, nerve stimulator)
• Have a condition for which exercise or transcutaneous stimulation is contraindicated
• Have a severe acute medical issue that in the investigator's judgement would adversely affect the participant's participation in the study. Examples include, but are not limited to acute urinary tract infections, pressure sores, musculoskeletal injury, or unmanage blood pressure.
• Are currently pregnant or have given birth within the past 12 months
• Use walking as your primary means of movement around your home and the community.

Where it is running

• ICORD — Vancouver, British Columbia, Canada (enrolling)

Full record on ClinicalTrials.gov

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