Noninvasive Brain Stimulation to Enhance Cognition at Home Following a TBI.

Completed · Not applicable

Conditions studied: TBI Traumatic Brain Injury

In brief

The purpose of this study is to examine the feasibility and preliminary efficacy of using transcutaneous vagus nerve stimulation (tVNS) at home, to enhance cognitive recovery in patients with mild-moderate traumatic brain injury (TBI).

Key facts

Study ID

NCT07428980

Run by

Shirley Ryan AbilityLab

People needed

7

Starts

2026-01-09

Expected to finish

2026-04-27

Last updated by the study team

2026-06-18

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-75 years.
• Formally diagnosed with traumatic brain injury.
• Ability to independently use a keyboard.
• Able to understand and communicate in English (according to clinical judgment).
• Able to independently provide consent to participate.

You may not qualify if…

• Acute medical issues requiring close physician or nursing monitoring.
• Bioelectrical implants, cerebral shunts, including pacemakers.
• Anyone with sore or diseased skin area in the ear
• Pregnancy or persons who are lactating.
• Cardiac arrhythmia.
• Epilepsy or seizure disorders.
• Significant gross or fine motor weakness.
• Significant, ongoing communication or comprehension impairments (such as aphasia) that would affect an individual's ability to complete the required assessments.
• Severely impaired memory retention (Score lower than 3 in the 3 Word Delayed Recall test attached to this submission).
• Current major depression diagnosis.

Where it is running

• Shirley Ryan AbilityLab — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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