AV Node Ablation and CONDUCTion System Pacing for Atrial Fibrillation With Preserved Left Ventricular Function
Recruiting now · Not applicable
Conditions studied: Atrial Fibrillation, Atrial Arrhythmia
In brief
AVA CONDUCT is a prospective, multicenter, randomized study with single blinding, comparing left bundle branch area (LBBA) pacing with right ventricular (RV) pacing following AV node ablation in terms of clinical, functional, and electrophysiological outcomes. The primary hypothesis is that pacing-induced cardiomyopathy, defined as a decrease in LVEF by 10% or more from baseline to an absolute value below 50%, occurs significantly more frequently in patients receiving RV pacing compared with LBBA pacing. Secondarily, LBBA pacing is expected to maintain comparable procedural safety while providing better cardiac function, resulting in improved quality of life and functional capacity compared with conventional RV pacing.
Key facts
- Study ID
- NCT07428967
- Run by
- St. Josefs-Hospital Wiesbaden GmbH
- People needed
- 86
- Starts
- 2026-02-01
- Expected to finish
- 2029-12-31
- Last updated by the study team
- 2026-02-24
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- History of symptomatic AF (EHRA IIb - IV) despite guideline-indicated medical or interventional therapy
- Preserved LVEF (≥ 50%, assessed by echocardiography, Simpson's biplane method)
- AV node ablation scheduled independently of possible study participation
- Age ≥ 18 years
- Consent capacity
You may not qualify if…
- Impaired LVEF (< 50%)
- Pre-implanted pacemaker
- Contraindication for pacemaker implantation or AV node ablation (see chapter 5.3 for details)
- High grade (III°) left cardiac valvular disease
- Surgical coronary revascularization (within the last 30 days) or current triple therapy after stent PCI
- Body-mass-index > 40 kg/m2
- Pregnancy
- Inability to give written informed consent
- Life expectancy < 12 months
Where it is running
- St. Josefs-Hospital Wiesbaden GmbH — Wiesbaden, Germany (enrolling)
- Evangelisches Krankenhaus Hagen-Haspe — Hagen, Germany
Full record on ClinicalTrials.gov
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