Extrinsic Tooth Whitening Evaluation of a Whitening Toothpaste

Completed · Not applicable

Conditions studied: Stain Removal Efficacy

In brief

This randomized, examiner-blind, parallel-group clinical study evaluated the effectiveness of a whitening toothpaste compared with a control toothpaste in removing extrinsic tooth stain over six weeks of twice-daily unsupervised use. Adult subjects were assessed at baseline and after 7, 14, 28, and 42 days of product use using the Macpherson Modification of the Lobene Stain Index. Oral soft and hard tissues and subject-reported sensory responses were also evaluated throughout the study.

Key facts

Study ID

NCT07428603

Run by

Church & Dwight Company, Inc.

People needed

118

Starts

2024-08-08

Expected to finish

2024-09-20

Last updated by the study team

2026-02-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults 18-65 years in good general health
• Mean MLSI score ≥1.5 on labial surfaces of at least 8 of 12 anterior teeth
• Adequate oral hygiene and willingness to comply with study requirements
• Dental prophylaxis within past 18 months but not within past 3 months
• Willing to refrain from other whitening or oral care products during the study

You may not qualify if…

• Significant medical conditions or oral pathology affecting assessments
• History of adverse reactions to oral hygiene products
• Orthodontic appliances or restorations interfering with stain assessment
• Moderate or advanced periodontitis
• Recent bleaching or whitening treatments
• Pregnant or nursing

Where it is running

• Salus Research, Inc. — Fort Wayne, Indiana, United States

Full record on ClinicalTrials.gov

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