Observational Study on the Use of Ultrasound to Recognize Superficial Endometriosis in a Specific Area of the Pelvis (the Uterosacral Ligaments)

Recruiting now

Conditions studied: Endometriosis (Diagnosis)

In brief

An observational, prospective, multicenter study conducted on patients of childbearing age undergoing laparoscopic surgery for early-stage benign or malignant gynecological disease. The study does not include changes to the standard care pathway.

Key facts

Study ID

NCT07427849

Run by

Casa di Cura Dott. Pederzoli

People needed

64

Starts

2026-02-17

Expected to finish

2026-08-01

Last updated by the study team

2026-02-25

Who can join

Age: 18 and older, up to 50. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• patients who need to undergo gynecological surgery with a laparoscopic approach for benign pathology (endometriosis, uterine fibroids, adenomyosis, chronic pelvic pain, benign ovarian cysts) or non-advanced malignant pathology (stage I endometrium and cervix, stage I and II ovary).
• patients who performed a level II gynecological ultrasound with an experienced operator in the preoperative pathway.
• technical possibility of performing a transvaginal ultrasound and the patient's willingness to undergo such an investigation.
• patients of childbearing age (18 - 50 years).
• Signing of informed consent.

You may not qualify if…

• presence of endometriosis deeply infiltrating the posterior compartment. This may interfere with the interpretation of uterosacral ligament (LUS) thickness as a specific marker of superficial endometriosis
• technical impossibility of performing a transvaginal ultrasound (patient virgo, patient refusal).
• incomplete ultrasound evaluation of the uterosacral ligaments for anatomical reasons or for the presence of endometriosis nodules from other sites with partial involvement of the LUS (uterosacral ligament).
• advanced malignant disease (>Stage I for endometrium and cervix, > Stage II for ovary)
• pelvic organ prolapse
• PID or other pelvic inflammatory diseases
• medical emergencies (ovarian torsion, hemoperitoneum)
• postmenopausal patients
• previous pelvic surgery

Where it is running

• Ospedale P. Pederzoli Casa di Cura Privata S.p.A. — Peschiera del Garda, Verona, Italy (enrolling)
• Policlinico Universitario Federico II — Naples, Napoli, Italy
• Policlinico Abano Terme — Abano Terme, Padova, Italy
• Presidio ospedaliero-universitario Santa Maria della Misericordia - Azienda Sanitaria Universitaria Friuli Centrale — Udine, Udine, Italy

Full record on ClinicalTrials.gov

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