Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients

Recruiting now · Not applicable

Conditions studied: Cancer, Lung, Colon Neoplasm, Neuropathy;Peripheral

In brief

This study aims to find out whether certain molecules in the blood, called microRNAs, are linked to how often and how severely people develop nerve damage from chemotherapy. The investigators will look at patients receiving cancer drugs known to affect the nerves, such as paclitaxel (used for lung cancer) and oxaliplatin (used for colorectal cancer).

Key facts

Study ID

NCT07427537

Run by

University Hospital, Clermont-Ferrand

People needed

90

Starts

2026-01-29

Expected to finish

2028-07-31

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient treated for colorectal cancer and scheduled to receive oxaliplatin-based adjuvant chemotherapy for at least 6 cycles, or
• Patient treated for lung cancer and scheduled to receive paclitaxel-based chemotherapy for at least 4 cycles.

You may not qualify if…

• Neurodegenerative disease (e.g., Parkinson's, Alzheimer's, etc.),
• History of stroke,
• Pre-existing neuropathy (QLQ-CIPN20 sensory score ≥ 15/100),
• Pain (NRS ≥ 4/10),
• Pregnant or breastfeeding women,
• Patients under guardianship, curatorship, deprived of liberty, or under legal protection

Where it is running

• CHU Clermont-Ferrand — Clermont-Ferrand, France (enrolling)

Full record on ClinicalTrials.gov

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