SwissNeuroRehab - HDHI

Recruiting now · Not applicable

Conditions studied: Stroke

In brief

High-dose, high-intensity (HDHI) neurorehabilitation has shown promise for improving functional outcomes after acquired brain injury (ABI), yet its feasibility and impact across different stages of care and real-world clinical settings remain insufficiently understood. The SwissNeuroRehab (SNR) initiative, bringing together Swiss rehabilitation centres to develop and evaluate innovative, technology-supported models of neurorehabilitation, provides the broader framework within which this study is conducted. Within this framework, a structured HDHI therapy pathway supported by CE-marked digital neurorehabilitation tools has been developed for delivery across inpatient, outpatient, and home environments in Switzerland. This multicentre, non-randomised interventional feasibility study evaluates the feasibility and preliminary clinical effects of implementing this HDHI rehabilitation pathway for adults with stroke in subacute and chronic stages. Participants will receive approximately 300 minutes per week of active, technology-supported training in addition to standard rehabilitation care, following an individually tailored pathway across settings. Standardised clinical assessments, patient-reported outcomes, documentation of rehabilitation procedures, and socioeconomic measures will be collected at baseline, discharge, and follow-up timepoints up to 12-15 months post-enrollment. The primary aim of the study is to assess the feasibility of the HDHI intervention within routine rehabilitation workflows across multiple Swiss centres. Feasibility will be evaluated through (i) adherence to at least half of the weekly 300-minute Active Training Time target and (ii) patients' perceived feasibility and satisfaction with the program. Secondary aims are to explore preliminary clinical and functional changes, patient-reported outcomes, and quantify socioeconomic impacts through dedicated surveys and cost data. Findings from this study will (i) determine whether a structured HDHI rehabilitation pathway can be feasibly implemented across diverse clinical contexts, (ii) provide initial estimates of clinical and socioeconomic outcomes to support planning of future controlled trials.

Key facts

Study ID: NCT07427511
Run by: Centre Hospitalier Universitaire Vaudois
People needed: 120
Starts: 2026-02-10
Expected to finish: 2028-05-31
Last updated by the study team: 2026-03-10

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Adults aged 18-85 years.
Confirmed diagnosis of stroke (ischemic or hemorrhagic) >7 days ago
Be able to sit unassisted
Able and willing to give informed consent
Have motor difficulties of the Upper Extremity and/or Lower Extremity
Willing to commit to program length \& daily training dose
Willing to have assessments at start and end of program
Signed informed consent

You may not qualify if…

Severe cognitive impairment
Uncontrolled seizure disorder or epilepsy - clinician's judgement)
Any medical condition that would compromise their safety (inability to communicate, vision or hearing impairment, heart condition that limits participation in exercise) and tolerability (cardiac contraindications)
Pain that would limit rehabilitation dose
Severe apraxia
Severe memory disorder
Severe hemispatial neglect
Plegia of the affected limb

Where it is running

Klinik Valens — Valens, Canton of St. Gallen, Switzerland (enrolling)
Centre hospitalier universitaire Vaudois — Lausanne, Canton of Vaud, Switzerland (enrolling)
Swiss Réhabilitation Sàrl — Sullens, Canton of Vaud, Switzerland (enrolling)
Lake Lucerne Institute — Vitznau, Canton of Lucerne, Switzerland
Universitätspital Zürich — Zurich, Canton of Zurich, Switzerland

Full record on ClinicalTrials.gov

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