The Role of Priors in Hallucinatory Perception in Parkinson's Disease

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Conditions studied: PARKINSON DISEASE (Disorder)

In brief

The goal of this observational study is to better understand the mechanisms of hallucinations in patients with Parkinson's disease. The main question it aims to answer is: Do prior expectations increase the rate of false perceptions during a visual stimulus detection task more in Parkinson's disease patients with visual hallucinations compared to those without? Participants will undertake a computer task involving face detection and a battery of neuropsychological tests.

Key facts

Study ID

NCT07427498

Run by

University Hospital, Grenoble

People needed

60

Starts

2026-03-01

Expected to finish

2028-11-01

Last updated by the study team

2026-02-27

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults diagnosed with Parkinson's disease (with or without visual hallucinations) or healthy volunteers.
• Age 18 - 85 years.
• Consent to participate.

You may not qualify if…

• Currently participating in another clinical or therapeutic trial involving the testing of a drug treatment.
• Inability to perform cognitive tests due to:
• Non-psychiatric (somatic) conditions likely to affect cognitive abilities. Peripheral sensory or motor deficits. Acute clinical conditions (e.g., agitation, impaired consciousness).
• Diagnosis of dementia.
• Individuals covered by Articles L1121-5 to L1121-8 of the French Public Health Code (Code de la Santé Publique), including:
• Pregnant women, women in labor, or breastfeeding mothers. Individuals deprived of liberty by judicial or administrative decision. Individuals receiving psychiatric care under Articles L. 3212-1 and L. 3213-1 (excluding those covered by Article L. 1121-8).
• Individuals admitted to a healthcare or social institution for purposes other than research.
• Minors or adults under legal guardianship or unable to express consent.
• Individuals with a hierarchical relationship to any professional involved in the study.
• Only for healthy volunteers:
• Personal history of diagnosed neurological disorders.
• Post-Inclusion Exclusion:
• Participants included in the study but found to have a MoCA score below 24 will be excluded from the study.

Where it is running

• Grenoble University Hospitals — La Tronche, France

Full record on ClinicalTrials.gov

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