Amygdala Insula Retraining in the Management of Perimenopause Symptoms

Recruiting now · Not applicable

Conditions studied: Perimenopause, Menopausal Complaints

In brief

The goal of this study is to evaluate a neuroplasticity-based mind-body intervention, Amygdala and Insula Retraining (AIR), compared to a wait-list control in individuals experiencing perimenopausal symptoms. Our research questions include: Does AIR reduce overall perimenopausal symptom burden compared to a wait-list control? Does AIR improve sleep disturbance, vasomotor symptom interference, fatigue, mood, anxiety, and quality of life in perimenopausal individuals? Are symptom changes associated with improvements in autonomic regulation and sleep parameters, as reflected by exploratory wearable measures including heart rate variability?

Key facts

Study ID

NCT07427459

Run by

Chronic Conditions Research Fund

People needed

160

Starts

2026-07-15

Expected to finish

2027-03-01

Last updated by the study team

2026-06-29

Who can join

Age: 38 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Experiencing perimenopausal symptoms
• Meets STRAW+10 criteria based on self-assessment (-2 to +1c)
• Able to read and understand English
• Access to internet

You may not qualify if…

• Pregnancy
• Presence of a severe psychiatric condition requiring immediate clinical intervention
• Uncontrolled thyroid disease or prolactinoma
• Active cancer treatment
• Inability to provide informed consent
• Any medical or psychiatric condition that, in the judgment of the investigator or study team, would interfere with safe participation or study completion

Where it is running

• Luther College Department of Psychology — Decorah, Iowa, United States (enrolling)

Full record on ClinicalTrials.gov

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