Cerebral Blood Flow in Term and Preterm Neonates Using Doppler Ultrasonography
Starting soon
Conditions studied: Cerebral Blood Flow
In brief
This study aims to evaluate cerebral blood flow in stable term and preterm newborns using Doppler ultrasonography. By measuring and comparing PSV, EDV, RI, and PI in the main brain arteries, the study seeks to identify normal physiological differences in cerebral perfusion across different gestational ages. The main goal is to establish reference values that can guide clinical monitoring, allow early detection of blood flow problems, and improve neuroprotective care in newborns.
Key facts
- Study ID
- NCT07427342
- Run by
- Assiut University
- People needed
- 200
- Starts
- 2026-04-15
- Expected to finish
- 2027-12-15
- Last updated by the study team
- 2026-02-23
Who can join
Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Term neonates ≥ 37 weeks of gestational age.
- Preterm neonates < 37 weeks' gestational age.
- Hemodynamically stable infants at the time of examination.
- Parental/guardian informed consent obtained.
- Within the first 48 hours after birth.
- Birth weight appreciate for gestational age.
You may not qualify if…
- Infants aged more than 48 hours after birth.
- Neonates with major congenital anomalies (cardiac, neurological, or craniofacial).
- Suspected or confirmed intracranial hemorrhage or brain malformations, such as intraventricular hemorrhage, may influence RI measurements and interfere with accurate assessment of cerebral blood flow.
- Neonates requiring inotropic support at the time of scan.
- Neonates with severe respiratory instability or mechanical ventilation (unless included intentionally).
- Infants with sepsis or metabolic derangements affecting cerebral perfusion.
Where it is running
- Assiut university — Asyut, Egypt
Full record on ClinicalTrials.gov
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