The Relationship Between Ultra-Processed Food Consumption and Oral Health

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Conditions studied: Ultra-processed Food

In brief

The goal of this observational study is to examine the potential relationship between ultra-processed food consumption and the presence of dental caries and periodontal disease, and to evaluate the role of the Ultra-Processed Food Index (UPFI) in this association. The main question it aims to answer is: Does increased consumption of ultra-processed foods raise the risk or severity of dental caries and periodontal disease in individuals? Participants will include individuals within a specified age range who voluntarily agree to participate in the study. Oral health status will be assessed through standard clinical parameters, including the presence of caries, plaque index, probing pocket depth, clinical attachment loss, and bleeding on probing. Dietary habits will be evaluated using a validated food frequency questionnaire, and individual UPFI scores will be calculated. The study will aim to observe and analyze the effects of ultra-processed food consumption on oral health outcomes.

Key facts

Study ID

NCT07427095

Run by

Recep Tayyip Erdogan University Training and Research Hospital

People needed

200

Starts

2026-04-27

Expected to finish

2026-10-26

Last updated by the study team

2026-02-24

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Individuals between the ages of 18 and 65,
• Individuals with at least 20 teeth,
• Not having received periodontal treatment in the last 6 months,
• Not having taken antibiotics, steroids, and/or nonsteroidal anti-inflammatory drugs in the last 3 weeks,
• Not having any autoimmune disease, osteoporosis, or cancer,
• Not using immunosuppressive drugs, oral contraceptives, or bisphosphonates,
• Not being pregnant,
• Not having an active infectious disease (acute hepatitis, tuberculosis, AIDS),
• Not using chronic medications that affect periodontal tissues (cyclosporine A, Phenytoin),
• Not having taken antioxidant supplements in the last 6 months.

You may not qualify if…

• Patients with endocrine or genetic disorders such as hypothyroidism, type 1 diabetes mellitus, or Cushing's syndrome
• Patients with active infectious disease
• Patients taking medications that may affect periodontal tissues
• Patients who have recently taken antibiotics (within 4 months)
• Patients with alcohol/drug use
• Patients with psychological disorders
• Patients with eating disorders, dementia
• Patients who are pregnant or breastfeeding
• Patients with any food allergies
• Patients who do not sign the informed consent form

Where it is running

• Department of Periodontology of the Faculty of Dentistry of Recep Tayyip Erdogan University — Rize, Rize Province, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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