Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration

Recruiting now · Not applicable

Conditions studied: Respiratory Distress Syndrome (Neonatal), Surfactant Deficiency Syndrome Neonatal

In brief

Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?

Key facts

Study ID

NCT07426016

Run by

University of Texas Southwestern Medical Center

People needed

100

Starts

2026-06-11

Expected to finish

2028-11-01

Last updated by the study team

2026-06-15

Who can join

Age: any, up to 0. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants born ≤28 weeks GA successfully resuscitated in the delivery room (DR) and maintained on CPAP • Need for surfactant in the first 36 hours of life based on clinical assessment and/or meeting threshold per unit protocol

You may not qualify if…

• Infants born ≥29 weeks GA or
• Infants with known congenital anomalies or
• Infants who are determined by the primary care team to receive comfort care only or
• Infants who are intubated at any time prior to surfactant administration

Where it is running

• Parkland Hospital — Dallas, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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