Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration
Starting soon · Not applicable · Has a placebo group
Conditions studied: Retinal Degeneration, Vision Impairment and Blindness
In brief
The goal of this clinical trial is to learn if transcranial magnetic stimulation (TMS) works to restore vision in adults with severe retinal degeneration. It will also learn about the safety of TMS treatment. The main questions it aims to answer are: 1. Does TMS treatment improve the visual function of participants? 2. What medical problems do participants have when receiving TMS treatment? Researchers will compare TMS treatment to a sham stimulation (identical procedures using a sham coil without effective magnetic field output) to see if TMS treatment works to restore their vision. Participants will: UndergoTMS treatment to a sham stimulation for consecutive 5 days Visit the clinic at 5 days, 4 weeks, 3 months, 6 months, 12 months after start of the treatment for checkups and tests
Key facts
- Study ID
- NCT07425717
- Run by
- Shanghai High Myopia Study Group
- People needed
- 136
- Starts
- 2026-06-01
- Expected to finish
- 2029-05-31
- Last updated by the study team
- 2026-02-23
Who can join
Age: 45 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- between 45 and 70 years old
- bilateral severe MMD (META-PM grades ≥ 3)
- no prior TMS history or contraindications to TMS
You may not qualify if…
- other significant ocular diseases, such as refractive media opacity, glaucoma, uveitis, ocular trauma, untreated retinal detachment, or lens dislocation
- received anti-vascular endothelial growth factor treatment or other ocular surgeries within 3 months
- history of epilepsy or family history of epilepsy, intracranial metal implants, or severe cerebrovascular diseases
- mental illness, cognitive impairment (MMSE score < 24), unable to communicate effectively
- severe heart disease, liver or kidney dysfunction, or coagulation disorders
- pregnant or lactating women
- currently participating in other clinical trials.
Where it is running
- Hong Kong Polytechnic University — Hong Kong, China
- Eye and Ear, Nose, Throat Hospital of Fudan University — Shanghai, China
- Huadong Hospital of Fudan University — Shanghai, China
- Shanghai Ninth People's Hospital — Shanghai, China
Full record on ClinicalTrials.gov
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